Cancer Metabolic and Immune Reprogramming: The Intimate Interaction Between Cancer Cells and Microenvironment
نویسنده
چکیده
ECM: Extracellular Matrix; CAFs: Cancer Associated Fibroblasts; TLRs: Toll-like Receptors; Ig: Immunoglobulin; RAG: Recombination Activating Genes; TCA: Tri Carboxylic Acid; MCT: Monocarboxylate Transporter; ROS: Reactive Oxygen Species; HK2: Hexokinase 2; PET: Positron Emission Tomography; PFK-1: 6-Phosphofructo-1-Kinase; PK: Pyruvate Kinase; SPs: Specificity Proteins; GFs: Growth Factors; PDGF: Platelet-Derived Growth Factor; TGF-β: Transforming Growth Factor-β; bFGF: basic Fibroblast Growth Factor; EMT: Epithelial-to-Mesenchymal Transition; TGFβ1: Transforming Growth Factor-β1; MDSCs: Myeloid-Derived Suppressor Cells
منابع مشابه
Crosstalk between Tumor Cells and Immune System Leads to Epithelial-Mesenchymal Transition Induction and Breast Cancer Progression
Herein, we review the current findings of how a variety of accessory cells could participate in shaping the tumor microenvironment and supporting the mechanisms by which cancer cells undertake the epithelial-mesenchymal transition (EMT). EMT, a complex of phenotypic changes, promotes cancer cell invasion and creates resistance to chemotherapies. Among the accessory cells present in the EMT, imm...
متن کاملO27: Interaction of Cancer Stem Cells and Microglia in Glioblastoma Multiforme
Malignant gliomas are highly invasive brain tumors with the occurrence of multiple microglia/macrophages in the tumor microenvironment. Macrophages/microglia that found in glioma microenvironment, as tumor-infiltrating immune cells, can play a harmful role in tumor progression. In addition, glioblastoma multiforme (GBM) contains multiple aberrant differentiation and tumorigenic cancer stem cell...
متن کاملThe Role of Inflammation and Changes of Adipose Tissue-Resident Immune Cells in Increasing the Risk of Cancer: A Narrative Review
The incidence of obesity, as a major health problem, has increased significantly over the past decades. This condition is associated with an increased risk of cancers, type 2 diabetes, and cardiovascular diseases. The current study aimed to investigate the effects of inflammation and changes of adipose tissue-resident immune cells on increasing the risk of cancer in obese individuals. In obesit...
متن کاملSTAT3 as a Key Factor in Tumor Microenvironment and Cancer Stem Cell
Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...
متن کاملInflammation, a Key Factor in Cancer Ambush
Inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, UV radiation, stress and etc. Persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from T cells. These molecules (e.g. IL-6, TNF-&alpha, IL-1&beta and IL-17) are mostly pleiotropic cytokines i...
متن کامل